Injury Chaos Ahead of Bills vs. 49ers: Who’s In and Who’s Out?

Injury Uncertainty Looms Over Bills vs. 49ers: Key Players in Doubt

After a long break, the Buffalo Bills are ready to host the San Francisco 49ers on Sunday night. But with both teams dealing with key injuries, the outcome of this highly anticipated matchup is far from certain.

For the Bills, they could take the field with just one starter missing. Offensive tackle Spencer Brown (ankle) is expected to return after sitting out in Week 11. He was a limited participant early in the week but has ramped up to full practice by midweek. Linebacker Matt Milano, who has been sidelined since October, is also trending toward playing after two full days of practice. Milano is expected to be activated off injured reserve before Sunday’s game, adding a significant boost to the defense.

However, there are still some uncertainties for Buffalo. Wide receiver Keon Coleman (wrist) has been limited in practice and could play, but he may be on a snap count. Defensive tackle DeWayne Carter (wrist) and offensive lineman Tylan Grable (groin) have been full participants in practice but are not yet on the active roster, so the Bills will need to make room for them before they can play.

Meanwhile, the 49ers are facing a more critical injury situation. Offensive tackle Trent Williams (ankle) is unlikely to play, as he’s been dealing with significant pain and using a knee scooter. Defensive stars Nick Bosa (hip/oblique) and Aaron Banks (concussion) are also questionable, with Bosa not practicing this week due to aggravated injuries. Quarterback Brock Purdy (shoulder) has been limited in practice, and with his status uncertain, backup Brandon Allen may be forced into another start.

The Buffalo Bills are finally back in action on Sunday night, but both teams are battling significant injuries. Buffalo could be missing just one starter, while the 49ers are dealing with several key players in doubt. Will Spencer Brown and Matt Milano return for the Bills, or will their absence hurt the team’s chances? And can Brock Purdy play through a shoulder issue, or will Brandon Allen take the reins for San Francisco? With injuries shaking up both rosters, this game could be a wild one. Stay tuned!